NTP CHEMICAL REPOSITORY

PICRIC ACID

-IDENTIFIERS

===========

*CATALOG ID NUMBER: 000065

*CAS NUMBER: 88-89-1

*BASE CHEMICAL NAME: PICRICACID

*PRIMARY NAME: PICRIC ACID

*CHEMICAL FORMULA: C6H3N3O7

*STRUCTURAL FORMULA:

*WLN: WNR BQ CNW ENW

*SYNONYMS:

LYDDITE

PERTITE

SHIMOSE

1,3,5-TRINITROPHENOL

PICRONITRIC ACID

PHENOL TRINITRATE

2,4,6-TRINITROPHENOL

2-HYDROXY-1,3,5-TRINITROBENZENE

CARBAZOTIC ACID

MELINITE

NITROXANTHIC ACID

C.I. 10305

-PHYSICAL CHEMICAL DATA

======================

*PHYSICAL DESCRIPTIONS: LITERATURE: Pale yellow crystals

REPOSITORY: Yellow crystals

*MOLECULAR WEIGHT: 229.12

*SPECIFIC GRAVITY: 1.763

*DENSITY: 1.763 g/mL

*MP (DEG C): 121.8 - 123 C

*BP (DEG C): >300 C (Sublimes/explodes)

*SOLUBILITIES:

WATER : 1-10 mg/mL @ 24 C (RAD)

DMSO : >=100 mg/mL @ 23 C (RAD)

95% ETHANOL : 10-50 mg/mL @ 23 C (RAD)

METHANOL : Not available

ACETONE : >=100 mg/mL @ 23 C (RAD)

TOLUENE : Not available

OTHER SOLVENTS:

Methanol: Soluble

Acetic acid: Soluble

Pyrimidene: Soluble

Chloroform: 1 gm/35 ml

ETHER : 1 gm/65 mL

BENZENE: 1 gm/10 mL

*VOLATILITY:

Vapor pressure: < 1 mm Hg

Vapor density : 7.90

*FLAMMABILITY(FLASH POINT):

This compound has a flash point of 150 C (302 F) and it can explode when

heated. Fires should be controlled from a safe distance. Use a dry chemical

or Halon extinguisher. Do not attempt to control large fires involving this

material, but, rather, keep surrounding areas cool with a water spray and

contact an explosive expert. The autoignition temperature is 299 C (572 F).

*UEL: Not available LEL: Not available

*REACTIVITY:

Reacts with metals, especially copper, lead and zinc, and with calcium,

ammonium, concrete and bases to form highly explosive and shock sensitive

picrate salts. Can also react vigorously with reducing agents. It is

also incompatible with all oxidizable substances, albumin, gelatin and

alkaloids.

*STABILITY:

This compound can explode when rapidly heated or severely shocked. It may

also be sensitive to exposure to air. Solutions of this chemical should be

stable for 24 hours under normal lab conditions (RAD).

*OTHER PHYSICAL DATA:

Impact sensitivity: 82 cm.

This compound is a more powerful explosive than TNT.

Refractive index: 1.763

pka 0.29 (25 C, H2O)

Odorless

Intensely bitter crystals

log P oct 2.03

-TOXICITY

========

*NIOSH REGISTRY NUMBER: TJ7875000

*TOXICITY: (abbreviations)

typ. dose mode specie amount unit other

LDLo scu dog 60 mg/kg

LDLo unk dog 60 mg/kg

LDLo orl cat 250 mg/kg

LDLo orl rbt 120 mg/kg

LDLo orl gpg 100 mg/kg

LDLo scu pgn 200 mg/kg

LDLo scu frg 200 mg/kg

*AQTX/TLM96: Not available

*SAX TOXICITY EVALUATION:

THR: MUTATION data. HIGH via oral, dermal and subcutaneous routes. An

irritant and an allergen. Dermal exposure may cause local and systemic

allergic reactions. Can cause allergic as well as irritative dermatitis.

*CARCINOGENICITY: Not available

*MUTAGENICITY:

Mutation Data:

mmo-esc 1800 ppm

mmo-sat 5 umol/plate

mma-sat 5 umol/plate

sln-dmg-orl 1250 umol/L

*TERATOGENICITY: Not available

*STANDARDS, REGULATIONS & RECOMMENDATIONS:

OSHA: Federal Register (1/19/89) and 29 CFR 1910.1000 Subpart Z

Transitional Limit: PEL-TWA 0.1 mg/m3 (skin) [610]

Final Limit: PEL-TWA 0.1 mg/m3 (skin) [610]

ACGIH: TLV-TWA 0.1 mg/m3 (skin); STEL 0.3 mg/m3, with a notice of intent to

delete STEL [610]

NIOSH Criteria Document: None

NFPA Hazard Rating: Health (H): None

Flammability (F): None

Reactivity (R): None

*OTHER TOXICITY DATA:

Standards and Regulations: DOT-Hazard: Class A explosive; Label: Explosive A

Review: Toxicology Review

Status: "NIOSH Manual of Analytical Methods" Vol. 4

"NIOSH Manual of Analytical Methods" to be revised by June 1985

Reported in EPA TSCA Inventory, 1983

EPA Genetic Toxicology Program, January 1984

-OTHER DATA (Regulatory)

=======================

*PROPER SHIPPING NAME (IATA): Trinitrophenol, wetted

*UN/ID NUMBER: UN1344

*HAZARD CLASS: 4.1 SUBSIDIARY RISK: None PACKING GROUP: I

*LABELS REQUIRED: Flammable solid

*PACKAGING: PASSENGER: PKG. INSTR.: 416 MAXIMUM QUANTITY: 1 kg

CARGO : PKG. INSTR.: 412 MAXIMUM QUANTITY: 15 kg

*SPECIAL PROVISIONS: A40

*USES:

Explosives; matches; leather industry; electric batteries; etching copper;

manufacture of colored glass; textile mordant; reagent; antiseptic; astrin-

gent.

*COMMENTS: Not available

-HANDLING PROCEDURES

===================

*ACUTE/CHRONIC HAZARDS:

This chemical is absorbed through the skin and is an irritant. On decom-

position this compound emits highly toxic fumes and can explode. It is also

explosive if severely shocked.

*MINIMUM PROTECTIVE CLOTHING:

If Tyvek-type disposable protective clothing is not worn during

handling of this chemical, wear disposable Tyvek-type sleeves taped to

your gloves.

*RECOMMENDED GLOVE MATERIALS: Not available

*RECOMMENDED RESPIRATOR:

Where the neat test chemical is weighed and diluted, wear a NIOSH-

approved half face respirator equipped with a combination filter cartridge,

i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid

gas, SO2 and a high efficiency particulate filter).

*OTHER: Not available

*STORAGE PRECAUTIONS:

You should store this chemical under an inert atmosphere in a refrigerator

and away from all organic compounds. Protect this container from shock or

damage. STORE AWAY FROM SOURCES OF IGNITION.

*SPILLS AND LEAKAGE:

Should a spill occur while you are handling this chemical, FIRST REMOVE

ALL SOURCES OF IGNITION, then you should dampen the solid spill material with

ethanol and transfer the dampened material to a suitable container. Use

absorbent paper dampened with ethanol to pick up any remaining material. Seal

the absorbent paper, and any of your clothes, which may be contaminated,in a

vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated

surfaces with ethanol followed by washing with a soap and water solution. Do

not reenter the contaminated area until the Safety Officer (or other responsi-

ble person) has verified that the area has been properly cleaned.

*DISPOSAL AND WASTE TREATMENT:

Not available

-EMERGENCY PROCEDURES

====================

*SKIN CONTACT:

IMMEDIATELY flood affected skin with water while removing and isolating

all contaminated clothing. Gently wash all affected skin areas thoroughly

with soap and water.

IMMEDIATELY call a hospital or poison control center even if no symptoms

(such as redness or irritation) develop.

IMMEDIATELY transport the victim to a hospital for treatment after

washing the affected areas.

*INHALATION:

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.

IMMEDIATELY call a physician and be prepared to transport the victim to a

hospital even if no symptoms (such as wheezing, coughing, shortness of breath,

or burning in the mouth, throat, or chest) develop.

Provide proper respiratory protection to rescuers entering an unknown

atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA)

should be used; if not available, use a level of protection greater than or

equal to that advised under Respirator Recommendation.

*EYE CONTACT:

First check the victim for contact lenses and remove if present. Flush

victim's eyes with water or normal saline solution for 20 to 30 minutes while

simultaneously calling a hospital or poison control center.

Do not put any ointments, oils, or medication in the victim's eyes without

specific instructions from a physician.

IMMEDIATELY transport the victim after flushing eyes to a hospital even if

no symptoms (such as redness or irritation) develop.

*INGESTION:

If the victim is conscious and not convulsing, give 1 or 2 glasses of

water to dilute the chemical and IMMEDIATELY call a hospital or poison control

center.

Generally, the induction of vomiting is NOT recommended outside of a

physician's care due to the risk of aspirating the chemical into the victim's

lungs. However, if the victim is conscious and not convulsing and if medical

help is not readily available, consider the risk of inducing vomiting because

of the high toxicity of the chemical ingested. Ipecac syrup or salt water may

be used in such an emergency. IMMEDIATELY transport the victim to a hospital.

If the victim is convulsing or unconscious, do not give anything by mouth,

ensure that the victim's airway is open and lay the victim on his/her side with

the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport

the victim to a hospital.

*SYMPTOMS:

Exposure to this chemical may cause nausea, vomiting, diarrhea, epigastric

pain, oliguria, anuria, albuminuria, hematuria, yellow staining of tissues,

pruritis, skin eruptions, nasal irritation and epistaxis, bronchitis, vertigo,

casts, anemia, weakness, stupor, fever, convulsions, myalgia and death.

*FIREFIGHTING: Not available

-SOURCES

=======

*SOURCES:

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of Chemical Substances. Microfiche Ed. National Institute for

Occupational Safety and Health. Cincinnati, OH. Quarterly

Updates. TJ8750000.

Weast, R.C. and M.A. Astle, Eds. CRC Handbook of Chemistry

and Physics. 63rd Ed. CRC Press, Inc. Boca Raton, FL.

1982. p. C-456, #11559.

Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed.

Chapman and Hall. New York. 1982. Vol. 5, pp. 5607-8, #T-04234.

Windholz, M., Ed. The Merck Index. 10th Ed. Merck and Co.

Rahway, NJ. 1983. p. 1068, #7288.

Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed.

Van Nostrand Reinhold. New York. 1984. p. 2230.

Verschueren, K. Handbook of Environmental Data on Organic

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Van Nostrand Reinhold. New York. 1979. p. 915

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Not listed.

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