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  He's Advanced Analytical Lab
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My research focuses on development and applications of the most advanced and innovative analytical techniques in solving the critical and emerging issues in food science. Surface-Enhanced Raman Spectroscopy (SERS) is a combination of Raman spectroscopy and nano-techniques. The use of metallic nanostructure enhances the Raman scattering more than a million times. We have developed various SERS based techniques for food safety and quality. Check out our recently published SERS review papers:

Guo, Huiyuan, Lili He*, and Baoshan Xing*. "Applications of surface-enhanced Raman spectroscopy in the analysis of nanoparticles in the environment." Environmental Science: Nano 4.11 (2017): 2093-2107. 10.1039/C7EN00653E

Zhang, Ye, Shaojie Zhao, Jinkai Zheng*, and Lili He*. 2017. "Surface-enhanced Raman spectroscopy (SERS) combined techniques for high-performance detection and characterization." TrAC Trends in Analytical Chemistry. http://dx.doi.org/10.1016/j.trac.2017.02.006

Yang, T., Wang, P., Guo, H., He, L.*, 2016. Surface-Enhanced Raman Spectroscopy: A Tool for All Classes of Food Contaminants. Reference Module in Food Sciences. Elsevier, pp. 1–8. doi: http://dx.doi.org/10.1016/B978-0-08-100596-5.21090-1

Pang, Shintaro, Tianxi Yang, and Lili He*. 2016. "Review of surface enhanced raman spectroscopic (SERS) detection of synthetic chemical pesticides."TrAC Trends in Analytical Chemistry.  doi:10.1016/j.trac.2016.06.017

Jinkai Zheng and Lili He*. 2014. Surface-Enhanced Raman Spectroscopy for the Chemical Analysis of Food. Comprehensive Reviews in Food Science and Food Safety. 13 (3), 317-328. http://onlinelibrary.wiley.com/doi/10.1111/1541-4337.12062/abstract

1. Food safety applications, chemical, microbial, and engineered nanoparticle contaminants.

2. Food quality applications, molecular interaction, stability, authenticity

Figure 1. In situ analysis of pesticide penetration.



Figure 2. Evaluation of removal of pesticides from apples using SERS mapping



Figure 3. The sandwich assay for optical and SERS detection of bacteria



Figure 4. Smartphone based optical detection of bacteria.

ligand ag

Figure 5. ligand based extraction and detection of AgNPs using SERS


Figure 6, simutanous determination of type, concentration and size of TiO2 using SERS


Figure 7. AgNP mirror


Funding acknowledgements

USDA-NIFA, DHS-NCFPD, NIH-SBIR with Aglitron Inc., PepsiCo Inc., American River Nutrition Inc., Diversified Laboratory, BASF, Inspecto, DSM.





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Office: Chenoweth 344
Tel.: (413) 545-5847
Email: lilihe at foodsci.umass.edu