Mixed Models and Analysis of Repeated Measures/Longitudinal Data
Homework Assignment #9

 


Developing Expressions for the Random Response Vector in a Nested Study


1. Searle describes a study in Chapter 3, p44-49. Read this discussion. Following this, using the notation discussed in class, and assuming the number of classes in the population is very large (virtually infinite), and the number of students in each class is also very large (virtually infinite):

  • A. Write a model for a randomly selected subject (j) from a randomly selected class (i) . Define the fixed and random effects in the model, and define parameters for the population.
  • B. Express a model for a vector of random variables corresponding to the responses in Table 3.1 (page 47), where the subjects from the first selected class are listed first, the second listed second, etc.
  • C. Let C denote expectation with respect to classes, and P denote expectation with respect to subjects. Write out expressions for the following:
    • i. The expected value with respect to P of the response vector.
    • ii. The variance with respect to P of the response vector.
    • iii. The expected value with respect to C and P of the response vector.
    • iv. The variance with respect to C and P of the response vector.
  • D. Define a matrix K that when pre-multiplied by the response vector will result in the mean response for each class. Using this matrix, evaluated expressions corresponding to parts i-iv in C of the vector of class means.


2. Searle describes a similar study in Chapter 3 with unequal numbers of subjects selected per class. The resulting data for the study are given in Table 3.2, page 52. Making similar assumptions as in problem 1,

  • A. Write a model for a randomly selected subject (j) from a randomly selected class (i) . Define the fixed and random effects in the model, and define parameters for the population. Assume that the unequal number of subjects selected are the result of the study design.
  • B. Express a model for a vector of random variables corresponding to the responses in Table 3.2 (page 52), where the subjects from the first selected class are listed first, the second listed second, etc.
  • C. Let C denote expectation with respect to classes, and P denote expectation with respect to subjects. Write out expressions for the following:
    • i. The expected value with respect to P of the response vector.
    • ii. The variance with respect to P of the response vector.
    • iii. The expected value with respect to C and P of the response vector.
    • iv. The variance with respect to C and P of the response vector.
  • D. Define a matrix K that when pre-multiplied by the response vector will result in the mean response for each class. Using this matrix, evaluated expressions corresponding to parts i-iv in C of the vector of class means.


Last Update: 3/24/98
Comments: Ed Stanek
Email:
stanek@schoolph.umass.edu
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