Molecular and Cardiovascular Physiology Laboratory


Cardiovascular disease remains the #1 cause of death from non-communicable diseases worldwide. The overall goal of our research is to understand the cells and signals that promote cardiovascular health, repair and regeneration.

One of the earliest signs of cardiovascular disease is the reduction in vascular endothelial function.  Endothelium, the cell layer at the blood-vessel interface, is responsible for vasodilation and constriction, coagulation and fibrinolytic activity, permeability and adhesion, and growth and differentiation of vessels.  Damage to the endothelium is evident prior to atherosclerosis and is therefore a pre-clinical marker of disease. Endothelial repair occurs via resident endothelial cells local to the site of damage and vascular regenerative cells, that can come from the bone marrow or the local environment. 

Circulating and resident cell types have angiogenic potential including hematopoietic stem cells, monocytes, fibroblasts, and pericytes.  These cells communicate with other cell types and influence the cardiovascular environment through the production of cytokines and chemokines that are angiogenic and/or inflammatory.  Physical activity is known to confer positive cardiovascular benefits and decrease cardiovascular disease risk.  We aim to evaluate how physical activity modulates these cells and their angiogenic and inflammatory signal communication to better understand their contribution to cardiovascular health.  Results from our work may provide novel targets and strategies to reduce the overall cardiovascular disease burden.


Laboratory Overview


106 Totman Building

30 Eastman La.

Department of Kinesiology

University of Massachusetts

Amherst, MA 01003






Department of KINESIOLOGY