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Marc Nascarella, Ph.D. Adjunct Assistant Professor
Education
Post-Graduate, Texas Tech Ph.D., Massachusetts M.S., Massachusetts B.S., (Cum laude), Norwich University
Course Material
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Marc A. Nascarella |
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University of Massachusetts Amherst Environmental Health Sciences Division Morrill Science Center I, N344 Amherst, MA 01003 Tel: (617) 395-5547 Fax: (617) 395-5001 Email: manascar@schoolph.umass.edu Web: http://people.umass.edu/manascar/
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Biography
Dr. Nascarella is an Adjunct Assistant Professor at the University of Massachusetts School of Public Health and Health Sciences where he lectures and conducts research in the areas of dose-response assessment and environmental/occupational health. Dr. Nascarella is a toxicologist working in a private consulting practice in Harvard Square and specializes in comprehensive chemical evaluations, dose-response assessment, and environmental epidemiological investigations. In addition to working as a consultant, Dr. Nascarella is a military veteran, who has held post-graduate academic research positions and has served as a toxicologist for a state pubic health agency.
Select Awards and Honors
· Society of Toxicology (SOT), Risk Assessment Specialty Section Award · Colgate-Palmolive/SOT Award for Alternative Methods Research · Entomological Society of America, SW Chapter, Doctoral Research Award · National Science Foundation, Summer Research Assistant · Institute of Environmental and Human Health, Presentation Award · Society for Risk Analysis, Dose-Response Specialty Group Award · Delta Omega Public Health Honor Society, Presentation Award · United States Public Health Service Traineeship
Professional Affiliations
International Dose-Response Society · Northeast Regional Chapter of the Society of Toxicology · Sigma Xi, The Scientific Research Society · Society for Risk Analysis · Society of Toxicology ·American Association for the Advancement of Science · New England Regional Chapter of the Society for Risk Analysis
Research Interests
In the field of toxicology, perhaps the most fundamental question is at what dose (x) does a specific effect (y) occur? Answering this question is essential for the safety evaluation of chemicals used as pharmaceuticals, as well as a determination of risk from chemicals that we are exposed to in the environment. In the laboratory evaluation of both types of chemical agents, the field of toxicology is rapidly moving towards the use of high-throughput screenings (HTS), where there is in vitro (meaning literally in glass) testing of many agents, at a single time. As opposed to the traditional in vivo (animal) toxicology studies, these studies are usually employed as an initial first-tiered, rapid, massive screening procedure to identify chemicals for follow-up analysis. The selection of agents for follow-up analysis can only be presumed when there is a reasonably high signal (response) to noise (variability) ratio. Within this context, the screening and selection process is greatly impacted by the consistency of responses observed within various replications.
Dr. Nascarella’s current line of research involves studying the dose-response relationships of a number of HTS assays to understand basic questions in dose-response metrics. He works with an interdisciplinary team at the Northeast Regional Environmental Public Health Center to evaluate HTS results from bacteria, yeast, and human cell lines, for both putative pharmaceutical agents and environmental chemicals. |
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