Complex & Integrative
Metabolic Systems to Improve Food Technologies and Combat Global Diet and
Environment-Linked Chronic Diseases
Complex Metabolic Systems for
Sustainable Community Development
Current Research
Focus:
1) Biotechnology and Metabolic Biology of
Functional Foods & Bioactives.
2) Global Food Systems Biology Concepts
& Innovations to Combat Diet-linked Chronic Diseases and Advancing
Integrated Food Safety Strategies.
3) Food Diversity and Indigenous Food Systems
to Combat Diet-Linked Chronic Diseases and especially “Metabolic Syndrome”
Diseases.
4) Integrated Food, Bioenergy & Soil
Biology Systems for Sustainable Community and Economic Development & Better
Community Health Solutions.
Specifically my current research interests focus on molecular and
physiological regulation of phenolic
metabolites and phenylpropanoid pathway
by proline-linked pentose phosphate pathway and redox-regulated pathways
in food plants, food-associated
bacteria, fungi and mammalian systems. In an applied context the
understanding of integrated metabolic interactions of diverse species in the
ecosystem is applied to finding solutions to food, health, energy,
environmental and water resource challenges faced by humanity in ecosystems
that is dynamic and impacted by Global Climate Changes.
This focus on phenolic-linked “Redox
Biology” is contributing substantially to innovative research advances in
the areas of Novel Bioactive Ingredient
Biosynthesis, Food Safety, Nutrition, Functional Foods, Biofuels and
Environmental adaptation of biological systems. The above concepts and
technologies can be targeted to specific needs of each local community globally
based on unique set of challenges and circumstances and converted into
sustainable economic development opportunities—COMPLEX METABOLIC SYSTEMS for
SUSTAINABLE COMMUNITY DEVELOPMENT.
Current Technology
Application Categories:
a) Food
Biotechnology:
**Genetic and
physiological regulation of synthesis and mobilization of phenolic antioxidants,
anti-microbial, anti-inflammatory, cancer chemo-preventive metabolites,
phyto-estrogens and flavors in food
plants and by Microbial-based solid
state bio-processing of cereals, grain legumes, fruits and vegetables with
focus on phenolic metabolites
and role of proline-linked pentose
phosphate pathway and Redox Biology in phenolic biosynthesis.
**Molecular and
Biochemical Bioassay models using bacterial, yeast, mammalian cell culture and mice
models to screen antioxidants, anti-microbial, anti-cancer and immune
modulating phenolic phytochemicals and role of proline-linked pentose phosphate pathway and antioxidant enzyme
response pathway.
b) Metabolic & Food
Systems Biology:
**Use of metabolic
critical control points of cellular energy pathways to design functional foods
to combat diet-linked chronic diseases and food safety challenges.
**Integration
of Proline-linked Redox Biology to understand cellular Redox protection and
prevention of disease development using Traditional Diet and Food Diversity.
**Lignocellulose-based
food and clean bioenergy systems and soil biology improvement based on role of
Redox Biology.
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