POTENTIAL APPLICATIONS OF PROLINE-LINKED PENTOSE PHOSPHATE PATHWAY (PLPPP) AND COUPLED REDOX RESPONSE PATHWAY

 

A)    Development of Functional Foods and Ingredients

1)      Screening elite phytochemical-producing clonal lines.

2)      Elicitor induction of phytochemicals in sprouts and seedlings.

3)      Solid-state bioprocessing of phytochemicals using fungal systems.

4)      Liquid bioprocessing of phytochemicals using yeast and bacteria.

5)      Phytochemical profiles and synergies as antimicrobials.

6)      Microbial synthesis of aromatic metabolites and nucleotides.

7)      Antioxidant metabolites from algae.

 

B)    Metabolic Biology of Disease Response

1)      PLPPP and coupled redox response pathways in understanding oxidation-linked diseases such as diabetes, CVD, cancer, arthritis and neuro-degeneration.

2)      Novel antimicrobial strategies through PLPPP and redox response regulation.

3)      Phytochemicals for cellular adaptation and endurance to stress—altitude, temperature, radiation and pollutants.

4)      Phytochemicals for Obesity and Obesity-linked diseases.

5)      Chemoprevention strategies for oxidation and infectious diseases.

6)      Innovative drug design concepts based on PLPPP and Redox response.

7)      Dietary phytochemical strategies for chronic bacterial infections (Ulcer, UTI & Dental caries).

 

C)    Environmental Applications

1)      Designing dietary phytochemicals to counter human exposure to aromatic pollutants and toxicants.

2)      PLPPP and Redox response pathway models for investigating toxicity and safety of drugs and pharmaceuticals.

3)      PLPPP and Redox response pathway models for investigating general chemical toxicity.

4)      Phytoremdiation of aromatic pollutants.

5)      Bio-addendum from Bioprocessing wastes and Bio-inoculants for Bioremediation of aromatic pollutants.

6)      Use of biological wastes such as fishery wastes for plant growth and productivity.

7)      Bio-addendums and Bio-inoculants for enhancing stress adaptation of tissue cultures, nursery seedlings and early stage transplants.

8)   Role of Proline as an osmolyte for stress tolerance in plants

9)    Role of Proline as an osmolyte for stress tolerance in microbial systems

 

D)    Developmental Physiology of PLPPP in Biological Systems

1)   Original contributions of Dr. James Phang on the role of PLPPP in purine metabolism in human and animal cells

2)   Plant somatic embryogenesis (Apiaceae and Graminae) and shoot organogenesis (melon cotyledon).

3)   Other contributions of the role of proline in human and animal systems

4)   Fruit development (raspberry, strawberry and blueberry) and post-harvest physiology (banana and pear).

5)      Plant (seed) reproductive development under water and salinity stress (legumes, cereals and Solanaceae).

6)      Egg and embryo development (poultry and fish).

7)      Insect morphogenesis (silk worm and honey bee).

8)      Color development of autumn leaves (maple).

9)      Spring flower bloom (apple and cherry) and vegetative development (gingko).

10)      Fruiting body development in edible mushrooms.

11)      Earthworm development under pollutant stress.