Mechanism of Action of Phenolic Phytochemicals

Eucaryotic Systems and Regulation of in vivo Antioxidant Enzyme Response through Proline-Linked Pentose Phosphate Pathway

Review Papers

  • Shetty, K. (2005) Rosmarinic acid biosynthesis and mechanism of action. In: Food Biotechnology, 2nd Edition [Shetty, K., Paliyath, G., Pometto, A.L. III and Levin, R.E. (eds)]. CRC Press, Boca Raton, FL. Pages 825-845.
  • McCue, P. and Shetty, K. (2005) Potential Health Benefits of Soybean Isoflavonoids and Related Phenolic Antioxidants. In: Food Biotechnology, 2nd Edition [Shetty, K., Paliyath, G., Pometto, A.L. III and Levin, R.E. (eds)]. CRC Press , Boca Raton, FL. Pages 771-787.
  • Vattem, D.A. and Shetty, K. (2005) Functional phytochemicals from cranberries: their mechanism of action and strategies to improve functionality. In: Food Biotechnology, 2nd Edition [Shetty, K., Paliyath, G., Pometto, A.L. III and Levin, R.E. (eds)]. CRC Press, Boca Raton, FL. Pages 789-823.
  • Vattem, D.A. and Shetty, K (2005) Biological functionality of ellagic acid; A Review. J. Food Biochemistry, 29:234-266.
  • Shetty, K. and Wahlqvist, M.L. (2004) A model for the role of proline-linked pentose phosphate pathway in phenolic phytochemical biosynthesis and mechanism of action for human health and environmental applications. Asia Pacific J. Clinical Nutrition, 13: 1-24.
  • Shetty, K. (2004) Role of proline-linked pentose phosphate pathway in biosynthesis of plant phenolics for functional food and environmental applications; A review. Process Biochemistry, 39:789-804.
  • McCue, P. and Shetty, K. (2004) A hypothetical model for the action of soybean isoflavonoids against cancer involving a shift to proline-linked energy metabolism through activation of the pentose phosphate pathway. Food Biotechnology, 18: 19-37.
  • Shetty, K and McCue, P. (2003). Phenolic antioxidant biosynthesis in plants for functional food application: Integration of Systems Biology and Biotechnological Approaches. Food Biotechnology, 17:67-97.

Journal Papers

  • Lee, O-H., Kwon, Y-I., Apostolidis, E., Shetty, K. and Kim., Y-C. (2011). Rhodiola-induced inhibition of adipogenesis involves antioxidant response associated with pentose phosphate pathway. Phytotherapy Ressearch, 25: 106-115.
  • Sarkar, D., Bhowmik, P.C., Kwon, Y-I. and Shetty, K. (2011). The role of proline-associated pentose phosphate pathway in cool-season turfgrasses after UV-B exposure. Environmental and Experimental Botany, 70: 251-258.
  • Sarkar. D., Bhowmik,P.C. and Shetty. K. (2010) Effects of marine peptide and chitosan oligosaccharide on high and low phenolic creeping bentgrass clonal lines and improvement of antioxidant enzyme response. Agronomy Journal, 102:981-989.
  • Kwon, Y-I., Apostolidis, E., Kim, Y-C. and Shetty, K. (2009) Over-expression of proline-linked antioxidant pathway and modulation of phenolic metabolites in long life span clonal line of Origanum vulgare in response to UV-radiation. J. Food Biochemistry, 33:649-673.
  • Sarkar, D., Bhowmick, P., Kwon, Y-I. and Shetty, K. (2009) Clonal response to cold tolerance in creeping bentgrass and role of proline-linked pentose phosphate pathway. Bioresource Technology, 100: 5332-5339.
  • Sarkar, D., Bhowmick, P., Kwon, Y-I. and Shetty, K. (2009) Cold acclimation responses of three cool-season turf grasses and role of proline-associated pentose phosphate pathway. J. Amer. Soc. Hort. Sci. 134: 210-220
  • Randhir, R. and Shetty, K. (2007) Elicitation of the proline-linked pentose phosphate pathway metabolite and antioxidant enzyme response by ascorbic acid in dark germinated fava bean sprouts. J. Food Biochemistry, 31: 485-508.
  • Burguieres, E., McCue, P., Kwon, Y-I. and Shetty, K. (2007) Effect of vitamin C and folic acid on seed vigor response and phenolic-linked antioxidant activity. Bioresource Technology, 98: 1393-1404.
  • Randhir, R., Vattem, D.A. and Shetty, K. (2006) Antioxidant enzyme response studies in H2O2-stressed porcine muscle tissue following treatment with fava bean sprout extract and L-DOPA. J. Food Biochemistry, 30: 671-698.
  • Randhir, R., Vattem, D.A. and Shetty, K. (2005) Antioxidant enzyme response studies in H2O2-stressed porcine muscle tissue following treatment with Oregano phenolic extracts. Process Biochemistry, 40: 2123-2134.
  • Vattem, D.A., Randhir, R. and Shetty, K. (2005) Cranberry phenolics-mediated elicitation of antioxidant enzyme response in fava bean (Vicia faba) sprouts. J. Food Biochemistry, 29: 41-70.
  • Vattem, D.A., Randhir, R. and Shetty, K. (2005) Cranberry phenolics-mediated antioxidant enzyme response in oxidatively stressed porcine muscle. Process Biochemistry, 40: 2225-2238 .
  • Shetty, P., Atallah, M.T. and Shetty, K. (2003) Stimulation of total phenolics, L-DOPA and antioxidant activity through proline-linked pentose phosphate pathway in response to proline and its analog in germinating fava beans (Vicia faba). Process Biochemistry, 38: 1707-1717.
  • Shetty, P., Atallah, M.T. and Shetty, K. (2002) Effects of UV treatment on the proline-linked pentose phosphate pathway for phenolics and L-DOPA synthesis in dark germinated Vicia faba. Process Biochemistry, 37:1285-1295.
  • McCue, P. and Shetty, K.(2002) A biochemical analysis of mungbean (Vigna radiata) response to microbial polysaccharides and potential phenolic-enhancing effects for nutraceutical applications. Food Biotechnology, 16:57-79.
  • Shetty, P., Atallah, M.T. and Shetty, K. (2001) Enhancement of total phenolic, L-DOPA and proline contents in germinating fava bean (Vicia faba) in response to bacterial elicitors. Food Biotechnology, 15:47-67.
  • Duval, B. and Shetty K. (2001) The stimulation of phenolics and antioxidant activity in pea (Pisum sativum) elicited by genetically transformed anise root extract. J.Food Biochemistry, 25:361-377.
  • Duval, B., Shetty, K. and Thomas, W. H. (1999) Phenolic compounds and antioxidant properties in the snow alga Chlamydomonas nivalis after exposure to UV light. J. Applied Phycology, 11:559-566.
  • Al-Amier, H., Mansour, B. M. M., Toaima, N. Korus, R. A and Shetty, K. (1999) Screening of high biomass and phenolic-producing clonal lines of Spearmint in tissue culture using Pseudomonas and azetidine-2-carboxylate. Food Biotechnology, 13:227-253.
  • Al-Amier, H., Mansour, B.M.M., Toaima. N., Korus, R.A. and Shetty, K. (1999). Tissue culture-based screening for selection of high biomass and phenolic-producing clonal lines of Lavender using Pseudomonas and azetidine-2--carboxylate. J. Agric.Food Chem., 47:2937-2943.
  • Andarwulan, N., Fardiaz, D., Wattimena, G.A. and Shetty, K. (1999). Antioxidant activity associated with lipid and phenolic mobilization during seed germination of Pangium edule Reinw. J. Agric. Food. Chem., 47:3158-3163.
  • Perry, P.L. and Shetty, K. (1999). A model for involvement of proline during Pseudomonas-mediated stimulation of rosmarinic acid. Food Biotechnology, 13:137-154.
  • Bela, J. and Shetty, K. (1999). Somatic embryogenesis in anise (Pimpinella anisum L.): The effect of proline on embryogenic callus formation and ABA on advanced embryo development. J. Food Biochemistry, 23:17-32.
  • Yang, R. and Shetty, K. (1998). Stimulation of rosmarinic acid in shoot cultures of oregano (Origanum vulgare) clonal line in response to proline, proline analog and proline precursors. J.Agric.Food Chem., 46:2888-2893.
  • Kwok, D. and Shetty, K. (l998). Effect of proline and proline analogs on total phenolic and rosmarinic acid levels in shoot clones of thyme (Thymus vulgaris L.). J. Food Biochemistry, 22:37-51.

 

Procaryotic (Bacterial) Antimicrobial Effects

Review Papers

 

Shetty, K. and Lin, Y-T. (2005) Phenolic antimicrobials from plants for control of bacterial pathogens. In: Food Biotechnology, 2nd Edition [Shetty, K., Paliyath, G., Pometto, A.L. III and Levin, R.E. (eds)]. CRC Press, Boca Raton, FL. Pages 1481-1505.

Journal Papers

 

  • Apostolidis, E., Kwon. Y-I., Shinde. R., Ghaedian. G. and Shetty, K. (2011). Inhibition of Helicobacter pylori by fermented milk and soymilk using select lactic acid bacteria and possible link to enrichment of lactic acid and phenolic content. Food Biotechnology, 25: 58 - 76.
  • Apostolidis, E., Kwon, Y-I. and Shetty, K. (2008) Inhibition of Listeria monocytogenes by oregano, cranberry and sodium lactate combinations in broth and cooked ground beef systems and likely mode of action through proline metabolism. International J. Food Microbiology, 128: 317-324.
  • Randhir, R. and Shetty, K. (2007) Improved alpha amylase and Helicobacter pylori inhibition of fenugreek by solid-state bioconversion by Rhizopus oligosporus. Asia Pacific J. Clinical Nutrition, 16: 382-392.
  • Randhir, R. and Shetty, K. (2007) Mung beans processed by a solid-state bioconversion improves phenolic content and functionality relevant for diabetes and ulcer management. Innovative Food Science and Emerging Technologies, 8: 197-204.
  • Kwon, Y.I., Apostolidis, E., Labbe, R.G. and Shetty, K. (2007) Inhibition of Staphylooccus aureus by phenolic phytochemicals of selected clonal herb species of Lamiaceae family and likely mode of action through proline oxidation. Food Biotechnology, 21: 71-89.
  • Ho, C-H., Lin, Y-T., Labbe, R.G. and Shetty, K. (2006) Inhibition of Helicobacter pylori by phenolic extracts of sprouted peas (Pisum sativum L. ). J. Food Biochemistry, 30: 21-34.
  • Lin, Y-T., Kwon, Y-I., Labbe, R.G. and Shetty, K. (2005) Inhibition of Helicobacter pylori and associated urease by oregano and cranberry phytochemical synergies. Applied Environmental Microbiology, 71: 8558-8564.
  • Lin, Y.T., Labbe, R.G. and Shetty, K. (2005) Inhibition of Vibrio parahaemolyticus in seafood systems using oregano and cranberry synergies and lactic acid. Innovative Food Science and Emerging Technologies, 6: 453-458.
  • McCue, P., Lin, Y-T., Labbe, R.G. and Shetty, K. (2005) Characterization of the effect of sprouting and solid-state bioprocessing by dietary fungus on the antinbacterial activity of soybean extracts against Listeria monocytogenes. Food Biotechnology, 19:121-136.
  • Vattem, D.A., Lin, Y-T. and Shetty, K. (2005) Enrichment of phenolic antioxidants and anti-Helicobacter pylori properties of cranberry pomace by solid-state bioprocessing. Food Biotechnology, 19: 51-68. 
  • Lin, Y-T., Vattem, D.A., Labbe, R.G. and Shetty, K. (2005) Enhancement of antioxidant activity and inhibition of Helicobacter pylori by phenolic phytochemical enriched alcoholic beverages. Process Biochemistry, 40: 2059-2065.
  • Vattem, D.A., Lin, Y-T., Ghaedian, R. and Shetty, K. (2005) Cranberry synergies for dietary management of Helicobacter pylori infections. Process Biochemistry, 40: 1583-1592.
  • Chun, S-S., Vattem, D.A., Lin, Y-T. and Shetty, K. (2005) Phenolic antioxidants from clonal oregano (Origanum vulgare) with antimicrobial activity against Helicobacter pylori. Process Biochemistry, 40: 809-816.
  • Correia, R.T.P., McCue, P., Vattem, D.A., Margarida, M.A.M., Macedo, G.R. and Shetty,K (2004) Amylase and Helicobacter pylori inhibition by phenolic extracts of pineapple wastes bioprocessed by Rhizopus oligosporus.  J. Food Biochemistry, 28: 419-434.
  • Randhir, R., Lin, Y-T. and Shetty, K. (2004) Phenolics, antioxidant and antimicrobial activity in dark germinated fenugreek sprouts in response to peptide and phytochemical elicitors. Asia Pacific Journal of Clinical Nutrition, 13:295-307.
  • Lin, Y-T., Labbe, R.G. and Shetty, K. (2004) Inhibition of Listeria monocytogenes in fish and meat systems using oregano and cranberry synergies. Applied and Environmental Microbiology, 70:5672-5678.
  • McCue,  P., Lin Y-T., Labbe, R.G. and Shetty, K. (2004) Sprouting and solid-state bioprocessing by Rhizopus oligosporus increase the in vitro antibacterial activity of aqueous soybean extracts against Helicobacter pylori. Food Biotechnology, 18: 229-249.
  • Vattem, D.A., Lin, Y-T., Labbe, R.G. and Shetty, K. (2004) Antimicrobial activity against select food-borne pathogens by phenolic antioxidants enriched cranberry pomace by solid-state bioprocessing using food-grade fungus Rhizopus oligosporus. Process Biochemistry, 39:1939-1946.
  • Randhir, R., Lin, Y-T. and Shetty, K. (2004) Stimulation of phenolics, Antioxidant and antimicrobial activities in dark germinated mung bean (Vigna radiata) Sprouts in response to peptide and phytochemical elicitors. Process Biochemistry, 39: 637-646.
  • Vattem, D.A., Lin, Y-T., Labbe, R.G. and Shetty, K. (2004) Phenolic antioxidant mobilization in cranberry pomace by solid-state bioprocessing using food grade fungus Lentinus edodes and effect on antimicrobial activity against select food-borne pathogens. Innovative Food Science and Emerging Technologies, 5: 81-91.
  • Seaberg, A., Labbe, R.L. and Shetty, K. (2003) Inhibition of Listeria monocytogenes by elite clonal extracts of oregano (Origanum vulgare). Food Biotechnology, 17:129-149.

 

Modulation of Specific Enzymes-Linked to Type 2 Diabetes, Hypertension and H. pylori

 

  • Barbosa, A.C.L., Pinto,M.D.S., Sarkar,D., Ankolekar, C., Greene. D. and Shetty. K. (2010). Varietal influences on anti-hyperglycemia properties of freshly harvested apples using in vitro assays models. J. Medicinal Food, 13: 1313-1323.  
  • Ranilla, L.G., Kwon, Y-I., Apostolidis, E. and Shetty. K. (2010) Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America. Bioresource Technology, 101: 4676-4689.
  • Pinto, M.D-S., Kwon, Y-I., Apostolidis, E., Lajolo, F.M., Genovese, M.I. and Shetty, K. (2010) Evaluation of red currants(Ribes rubrum L.), black currants (Ribes nigrum L.), red and green gooseberries(Ribes uva-crispa) for potential management of type 2 diabetes and hypertension using in vitro models. J. Food Biochemistry, 34: 639-660.
  • Ranilla, L.G., Kwon, Y-I., Genovese, M.I., Lajolo, F.M. and Shetty. K. (2010) Effect of thermal treatment on phenolic compounds and functionality linked to type 2 diabetes and hypertension management of Peruvian and Brazilian bean cultivars (Phaseolus vulgaris L.) using in vitro methods. J. Food Biochemistry, 34: 329-355.
  • Cheplick, S., Kwon, Y-I., Bhowmik, P. and Shetty, K. (2010) Phenolic-linked variation in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension. Bioresource Technology, 101: 404-413.
  • Adyanthaya, I., Kwon, Y-I., Apostolidis, E. and Shetty, K. (2010) Health benefits of apple phenolics from post-harvest stages for potential Type 2 diabetes management using in vitro models. J. Food Biochemistry, 34: 31-49.
  • Pinto, M.D-S., Kwon, Y-I., Apostolidis, E., Lajolo, F.M., Genovese, M.I. and Shetty, K. (2009) Potential of Ginkgo biloba L. leaves in the management of hyperglycemia and hypertension using in vitro models. Bioresource Technology, 100: 6599-6609.
  • Ranilla, L.G., Apostolidis, E., Genovese, M.I., Lajolo, F.M. and Shetty. K. (2009) Evaluation of indigenous grains from the Peruvian Andean region for anti-diabetes and anti-hypertension potential using in vitro methods. J. Medicinal Food, 12: 704-713..
  • Pinto, M.D-S., Ranilla, L.G., Apostolidis, E., Lajolo, F.M., Genovese, M.I. and Shetty, K. (2009). Evaluation of anti-hyperglycemia and anti-hypertension potential of native Peruvian fruits using in vitro models. J. Medicinal Food, 12: 278-291.
  • Randhir, R., Kwon, Y-I. and Shetty, K. (2009) Improved health-relevant functionality in dark germinated Mucuna pruriens sprouts by elicitation with peptide and phytochemical elicitors. Bioresource Technology, 100: 4507-4514.
  • Randhir, R., Kwon, Y-I., Lin, Y-T. and Shetty, K. (2009) Effect of thermal processing on phenolic associated health-relevant functionality of selected legume sprouts and seedlings. J. Food Biochemistry, 33: 89-112.
  • Ranilla, L.G., Kwon, Y-I., Genovese, M.I., Lajolo, F.M. and Shetty. K. (2008). Anti-diabetes and anti-hypertension potential of commonly consumed carbohydrates sweeteners using in vitro models. J. Medicinal Food, 11: 337-348.
  • Pinto, M.D-S., Kwon, Y-I., Apostolidis, E., Lajolo, F.M., Genovese, M.I. and Shetty, K. (2008) Functionality of bioactive compounds of Brazilian strawberry (Fragaria X Ananassa Duch.) cultivars: Evaluation of hyperglycemia and hypertension potential. J. Agric. Food Chemistry, 56: 4386-4392.
  • Randhir, R., Kwon, Y-I. and Shetty, K. (2008) Effect of thermal processing on phenolics, antioxidant activity and health-relevant functionality of select grain sprouts and seedlings. Innovative Food Science and Emerging Technologies, 9:355-364.
  • Kwon, Y-I., Apostolidis, E. and Shetty, K. (2008) In vitro studies of eggplant (Solanum  melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension. Bioresource Technology, 99: 2981-2988.
  • Kwon, Y-I., Apostolidis, E. and Shetty, K., (2008) Inhibitory potential of wine and tea against alpha-amylase and alpha-glucosidase for management of hyperglycemia linked to type 2 diabetes. J. Food Biochemistry, 32: 15-31.
  • Burguieres, E., McCue, P., Kwon, Y-I. and Shetty, K. (2008) Health-related functionality of phenolic enriched pea sprouts in relation to diabetes and hypertension management. J. Food Biochemistry, 32:3-14.
  • Cheplick, S., Kwon, Y-I., Bhowmick, P. and Shetty, K. (2007) Clonal variation in raspberry fruit phenolics and relevance for diabetes and hypertension management. J. Food Biochemistry, 31: 656-679.
  • Apostolidis, E., Kwon, Y-I., Ghaedian, R. and Shetty, K. (2007) Fermentation of milk and soymilk by Lactobacillus bulgaricus and Lactobacillus acidophilus enhances functionality for potential dietary management of hyperglycemia and hypertension. Food Biotechnology, 21: 217-236.
  • Randhir, R. and Shetty, K. (2007) Improved alpha amylase and Helicobacter pylori inhibition of fenugreek by solid-state bioconversion by Rhizopus oligosporus. Asia Pacific J. Clinical Nutrition, 16: 382-392.
  • Kwon, Y-I., Apostolidis, E., Kim, Y-C. and Shetty, K. (2007) Health benefits of traditional corn, beans and pumpkin; In vitro studies for hyperglycemia and hypertension management. J. Medicinal Foods, 10: 266-275.
  • Kwon, Y.I., Apostolidis, E. and Shetty, K. (2007) Evaluation of pepper (Capsicum annuum) for management of diabetes and hypertension. J. Food Biochemistry, 31: 370-385.
  • Randhir, R. and Shetty, K. (2007) Mung beans processed by a solid-state bioconversion improves phenolic content and functionality relevant for diabetes and ulcer management. Innovative Food Science and Emerging Technologies, 8: 197-204.
  • Apostolidis, E., Kwon, Y-I. and Shetty, K. (2007) Inhibitory potential of herb, fruit and fungal-enriched cheese against key enzymes linked to type 2 diabetes and hypertension. Innovative Food Science and Emerging Technologies, 8: 46-54.
  • Apostolidis, E., Kwon, Y-I. and Shetty, K. (2006) Potential of select Yogurts for diabetes and hypertension management. J. Food Biochemistry, 30: 699-717.
  • Apostolidis, E., Kwon, Y-I. and Shetty, K. (2006) Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pacific J. Clinical Nutrition, 15: 433-441.
  • Kwon, Y-I., Jang, H-D. and Shetty, K. (2006) Evaluation of Rhodiola crenulata and Rhodiola rosea for management of Type II diabetes and hypertension. Asia-Pacific J. Clinical Nutrition, 15: 425-432.
  •  Kwon, Y-I., Apostolidis, E. and Shetty, K. (2006) Anti-Diabetes functionality of Kefir culture-mediated        fermented soymilk supplemented with Rhodiola extracts. Food Biotechnology, 20: 13-29.
  • Kwon, Y-I., Vattem, D.A. and Shetty, K. (2006) Evaluation of clonal herbs of Lamiaceae species for management of diabetes and hypertension. Asia Pacific J. Clinical Nutrition, 15: 107-118.
  • Lin, Y-T., Kwon, Y-I., Labbe, R.G. and Shetty, K. (2005) Inhibition of Helicobacter pylori and associated urease by oregano and cranberry phytochemical synergies. Applied Environmental Microbiology, 71: 8558-8564.
  • McCue, P., Kwon, Y-I. and Shetty, K. (2005) Anti-amylase, anti-glucosidase and anti-angiotension I converting enzyme potential of select foods. J. Food Biochemistry, 29:278-294.
  • McCue, P., Kwon, Y-I. and Shetty, K. (2005) Anti-diabetic and anti-hypertensive potential of sprouted and solid-state bioprocessed soybean. Asia Pacific J. Clinical Nutrition, 14: 145-152.
  • McCue, P., Vattem, D.A. and Shetty, K. (2004) Inhibitory effect of clonal oregano extracts against porcine pancreatic amylase in vitro. Asia Pacific Journal of Clinical Nutrition, 13: 401-408.
  • Correia, R.T.P., McCue, P., Vattem, D.A., Margarida, M.A.M., Macedo, G.R. and Shetty,K (2004) Amylase and Helicobacter pylori inhibition by phenolic extracts of pineapple wastes bioprocessed by Rhizopus oligosporus.  J. Food Biochemistry, 28: 419-434.
  • McCue, P., and Shetty, K. (2004). Inhibitory effects of rosmarinic acid extracts on porcine pancreatic amylase and implications for health. Asia Pacific Journal of Clinical Nutrition, 13: 101-106.

 

Free Radical Scavenging in vitro Chemical Modulation

Review Paper

·         Vattem, D.A. and Shetty, K. (2005) Biochemical Markers for Antioxidant Functionality. In: Food Biotechnology, 2nd Edition [Shetty, K., Paliyath, G., Pometto, A.L. III and Levin, R.E. (eds)]. CRC Press , Boca Raton, FL. Pages 1207-1229.

Journal Papers

 

  • Ranilla, L.G., Kwon, Y-I., Apostolidis, E. and Shetty. K. (2010) Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America. Bioresource Technology, 101: 4676–4689.
  •  Pinto, M.D-S., Kwon, Y-I., Apostolidis, E., Lajolo, F.M., Genovese, M.I. and Shetty, K. (2010) Evaluation of red currants(Ribes rubrum L.), black currants (Ribes nigrum L.), red and green gooseberries(Ribes uva-crispa) for potential management of type 2 diabetes and hypertension using in vitro models. J. Food Biochemistry, 34: 639-660.
  • Ranilla, L.G., Kwon, Y-I., Genovese, M.I., Lajolo, F.M. and Shetty. K. (2010) Effect of thermal treatment on phenolic compounds and functionality linked to type 2 diabetes and hypertension management of Peruvian and Brazilian bean cultivars (Phaseolus vulgaris L.) using in vitro methods. J. Food Biochemistry, 34: 329-355.
  •  Cheplick, S., Kwon, Y-I., Bhowmik, P. and Shetty, K. (2010) Phenolic-linked variation in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension. Bioresource Technology, 101: 404-413.
  • Adyanthaya, I., Kwon, Y-I., Apostolidis, E. and Shetty, K. (2010) Health benefits of apple phenolics from post-harvest stages for potential Type 2 diabetes management using in vitro models. J. Food Biochemistry, 34: 31-49.
  • Pinto, M.D-S., Kwon, Y-I., Apostolidis, E., Lajolo, F.M., Genovese, M.I. and Shetty, K. (2009) Potential of Ginkgo biloba L. leaves in the management of hyperglycemia and hypertension using in vitro models. Bioresource Technology, 100: 6599-6609.
  • Ranilla, L.G., Apostolidis, E., Genovese, M.I., Lajolo, F.M. and Shetty. K. (2009) Evaluation of indigenous grains from the Peruvian Andean region for anti-diabetes and anti-hypertension potential using in vitro methods. J. Medicinal Food, 12: 704-713..
  • Pinto, M.D-S., Ranilla, L.G., Apostolidis, E., Lajolo, F.M., Genovese, M.I. and Shetty, K. (2009). Evaluation of anti-hyperglycemia and anti-hypertension potential of native Peruvian fruits using in vitro models. J. Medicinal Food,  12: 278-291.
  • Randhir, R., Kwon, Y-I. and Shetty, K. (2009) Improved health-relevant functionality in dark germinated Mucuna pruriens sprouts by elicitation with peptide and phytochemical elicitors. Bioresource Technology, 100: 4507-4514.
  • Randhir, R., Kwon, Y-I., Lin, Y-T. and Shetty, K. (2009) Effect of thermal processing on phenolic associated health-relevant functionality of selected legume sprouts and seedlings. J. Food Biochemistry, 33: 89-112.
  • Ranilla, L.G., Kwon, Y-I., Genovese, M.I., Lajolo, F.M. and Shetty. K. (2008). Anti-diabetes and anti-hypertension potential of commonly consumed carbohydrates sweeteners using in vitro models. J. Medicinal Food, 11: 337-348.
  • Pinto, M.D-S., Kwon, Y-I., Apostolidis, E., Lajolo, F.M., Genovese, M.I. and Shetty, K. (2008) Functionality of bioactive compounds of Brazilian strawberry (Fragaria X Ananassa Duch.) cultivars: Evaluation of hyperglycemia and hypertension potential. J. Agric. Food Chemistry, 56: 4386-4392.
  • Randhir, R., Kwon, Y-I. and Shetty, K. (2008) Effect of thermal processing on phenolics, antioxidant activity and health-relevant functionality of select grain sprouts and seedlings. Innovative Food Science and Emerging Technologies, 9:355-364.
  • Kwon, Y-I., Apostolidis, E. and Shetty, K. (2008) In vitro studies of eggplant (Solanum  melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension. Bioresource Technology, 99: 2981-2988.
  • Kwon, Y-I., Apostolidis, E. and Shetty, K., (2008) Inhibitory potential of wine and tea against alpha-amylase and alpha-glucosidase for management of hyperglycemia linked to type 2 diabetes. J. Food Biochemistry, 32: 15-31.
  • Burguieres, E., McCue, P., Kwon, Y-I. and Shetty, K. (2008) Health-related functionality of phenolic enriched pea sprouts in relation to diabetes and hypertension management. J. Food Biochemistry, 32:3-14.
  • Cheplick, S., Kwon, Y-I., Bhowmick, P. and Shetty, K. (2007) Clonal variation in raspberry fruit phenolics and relevance for diabetes and hypertension management. J. Food Biochemistry, 31: 656-679.
  • Apostolidis, E., Kwon, Y-I., Ghaedian, R. and Shetty, K. (2007) Fermentation of milk and soymilk by Lactobacillus bulgaricus and Lactobacillus acidophilus enhances functionality for potential dietary management of hyperglycemia and hypertension. Food Biotechnology, 21: 217-236.
  • Randhir, R. and Shetty, K. (2007) Improved alpha amylase and Helicobacter pylori inhibition of fenugreek by solid-state bioconversion by Rhizopus oligosporus. Asia Pacific J. Clinical Nutrition, 16: 382-392.
  • Kwon, Y-I., Apostolidis, E., Kim, Y-C. and Shetty, K. (2007) Health benefits of traditional corn, beans and pumpkin; In vitro studies for hyperglycemia and hypertension management. J. Medicinal Foods, 10: 266-275.
  • Kwon, Y.I., Apostolidis, E. and Shetty, K. (2007) Evaluation of pepper (Capsicum annuum) for management of diabetes and hypertension. J. Food Biochemistry, 31: 370-385.
  • Randhir, R. and Shetty, K. (2007) Mung beans processed by a solid-state bioconversion improves phenolic content and functionality relevant for diabetes and ulcer management. Innovative Food Science and Emerging Technologies, 8: 197-204.
  • Apostolidis, E., Kwon, Y-I. and Shetty, K. (2007) Inhibitory potential of herb, fruit and fungal-enriched cheese against key enzymes linked to type 2 diabetes and hypertension. Innovative Food Science and Emerging Technologies, 8: 46-54.
  • Apostolidis, E., Kwon, Y-I. and Shetty, K. (2006) Potential of select Yogurts for diabetes and hypertension management. J. Food Biochemistry, 30: 699-717.
  • Apostolidis, E., Kwon, Y-I. and Shetty, K. (2006) Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pacific J. Clinical Nutrition, 15: 433-441.
  • Kwon, Y-I., Jang, H-D. and Shetty, K. (2006) Evaluation of Rhodiola crenulata and Rhodiola rosea for management of Type II diabetes and hypertension. Asia-Pacific J. Clinical Nutrition, 15: 425-432.
  •  Kwon, Y-I., Apostolidis, E. and Shetty, K. (2006) Anti-Diabetes functionality of Kefir culture-mediated        fermented soymilk supplemented with Rhodiola extracts. Food Biotechnology, 20: 13-29.
  • Kwon, Y-I., Vattem, D.A. and Shetty, K. (2006) Evaluation of clonal herbs of Lamiaceae species for management of diabetes and hypertension. Asia Pacific J. Clinical Nutrition, 15: 107-118.
  • Vattem, D.A., Jang, H-D., Levin, R.E. and Shetty, K. (2006) Synergism of cranberry phenolics with ellagic acid and rosmarinic acid for antimutagenic and DNA-protection functions. J. Food Biochemistry, 30: 98-116.
  • Min, B., Dawson, P.L. and Shetty, K. (2005) Antioxidant and bioactive films to enhance food quality and phytochemical production during ripening. Korean J. Food Sci. Ani. Resour. 25: 60-65.
  • Vattem, D.A., Lin, Y-T. and Shetty, K. (2005) Enrichment of phenolic antioxidants and anti-Helicobacter pylori properties of cranberry pomace by solid-state bioprocessing. Food Biotechnology, 19: 51-68. 
  • Lin, Y-T., Vattem, D.A., Labbe, R.G. and Shetty, K. (2005) Enhancement of antioxidant activity and inhibition of Helicobacter pylori by phenolic phytochemical enriched alcoholic beverages. Process Biochemistry, 40: 2059-2065.
  • McCue, P. and Shetty, K. (2005) Phenolic antioxidant mobilization during yogurt production from soymilk. Process Biochemistry, 40: 1791-1797.
  • McCue, P. and Shetty, K. (2005) A Model for the Involvement of Lignin Degradation Enzymes in Phenolic Antioxidant Mobilization from Whole Soybean During Solid-state Bioprocessing by Lentinus edodes. Process Biochemistry, 40: 1143-1150.
  • Chun, S-S., Vattem, D.A., Lin, Y-T. and Shetty, K. (2005) Phenolic antioxidants from clonal oregano (Origanum vulgare) with antimicrobial activity against Helicobacter pylori. Process Biochemistry, 40: 809-816.
  • Correia, R.T.P., McCue, P., Margarida, M.A.M., Macedo, G.R. and Shetty,K (2004) Solid-state bioconversion of guava waste mixed with soy flour using Rhizopus oligosporus to enhance phenolic antioxidants. J. Food Biochemistry, 28: 404-418.
  • McCue, P., Horii, A. and Shetty, K. (2004) Mobilization of phenolic antioxidants from defatted soybean powders by Lentinus edodes during solid-state fermentation is associated with enhanced production of  laccase. Innovative Food Science and Emerging Technologies, 5: 385-392.
  • Randhir, R., Lin, Y-T. and Shetty, K. (2004) Phenolics, antioxidant and antimicrobial activity in dark germinated fenugreek sprouts in response to peptide and phytochemical elicitors. Asia Pacific Journal of Clinical Nutrition, 13:295-307.
  • Correia, R.T.P., McCue, P., Margarida, M.A.M., Macedo, G.R. and Shetty,K (2004) Production of phenolic antioxidants by solid-state bioconversion of pineapple waste mixed with soy flour using Rhizopus oligosporus. Process Biochemistry, 39:2167-2172.
  • Randhir, R. and Shetty, K. (2004) Microwave-induced stimulation of L-DOPA phenolics and antioxidant activity in fava bean (Vicia faba) for Parkinson's diet. Process Biochemistry, 39: 1775-1784.
  • McCue, P. and Shetty, K. (2004) A role for amylase and peroxidase-linked polymerization in phenolic antioxidant mobilization in dark-germinated soybean and implications for health. Process Biochemistry, 39: 1785-1791.
  • Randhir, R., Vattem, D. and Shetty, K. (2004) Soild-state bioconversion of fava bean by Rhizopus oligosporus for enrichment of phenolic antioxidants and L-DOPA. Innovative Food Science and Emerging Technologies, 5: 235-244.
  • Randhir, R., Lin, Y-T. and Shetty, K. (2004) Stimulation of phenolics, Antioxidant and antimicrobial activities in dark germinated mung bean (Vigna radiata) Sprouts in response to peptide and phytochemical elicitors. Process Biochemistry, 39: 637-646.
  • Vattem, D.A. and Shetty, K. (2003) Ellagic acid production and phenolic antioxidant activity in cranberry pomace mediated by Lentinus edodes using solid-state system. Process Biochemistry, 39: 367-379.
  • McCue, P., Horii, A and Shetty, K. (2003) Solid-state bioconversion of phenolic antioxidants from defatted powdered soybean by Rhizopus oligosprous: Role of carbohydrate cleaving enzymes. J. Food Biochemistry, 27: 499-512.
  • Shetty, P., Atallah, M.T. and Shetty, K. (2003) Stimulation of total phenolics, L-DOPA and antioxidant activity through proline-linked pentose phosphate pathway in response to proline and its analog in germinating fava beans (Vicia faba). Process Biochemistry, 38: 1707-1717.
  • McCue, P. and Shetty, K. (2003) Role of carbohydrate-cleaving enzymes in phenolic antioxidant mobilization from whole soybean fermented with Rhizopus oligosprorus. Food Biotechnology, 17:27-37. 
  • Randhir, R. and Shetty, K. (2003) Light-mediated fava bean (Vicia faba) response to phytochemical and protein elicitors and consequences on nutraceutical enhancement and seed vigor. Process Biochemistry, 38: 945-952. 
  • Vattem, D.A. and Shetty, K. (2002) Solid-state production of phenolic  antioxidants from cranberry pomace by Rhizopus oligosporus. Food Biotechnology, 16:189-210.
  • Shetty, P., Atallah, M.T. and Shetty, K. (2002) Effects of UV treatment on the proline-linked pentose phosphate pathway for phenolics and L-DOPA synthesis in dark germinated Vicia faba. Process Biochemistry, 37:1285-1295.
  • Randhir, R., Shetty, P. and Shetty, K.(2002) L-DOPA and total phenolic stimulation in dark germinated fava bean in response to peptide and phytochemical elicitors. Process Biochemistry, 37:1247-1256.
  • McCue, P. and Shetty, K.(2002) A biochemical analysis of mungbean (Vigna radiata) response to microbial polysaccharides and potential phenolic-enhancing effects for nutraceutical applications. Food Biotechnology, 16:57-79.
  • McCue, P. and Shetty, K.(2002) Clonal herbal extracts as elicitors of phenolic synthesis in dark-germinated mungbeans for improving nutritional value with implications for food safety. J. Food Biochemistry, 26:209-232.
  • Shetty, P., Atallah, M.T. and Shetty, K. (2001) Enhancement of total phenolic, L-DOPA and proline contents in germinating fava bean (Vicia faba) in response to bacterial elicitors. Food Biotechnology, 15:47-67.
  • Duval, B. and Shetty K. (2001) The stimulation of phenolics and antioxidant activity in pea (Pisum sativum) elicited by genetically transformed anise root extract. J.Food Biochemistry, 25:361-377.
  • Andarwulan, N. and Shetty, K. (2000) Stimulation of novel phenolic metabolite, epoxy-Psuedoisoeugenol-(2-Methylbutyrate)[EPB], in transformed anise (Pimpinella anisum L. ) root cultures by fish protein hydrolysates. Food Biotechnology,14:1-20.
  • Duval, B., Shetty, K. and Thomas, W. H. (1999) Phenolic compounds and antioxidant properties in the snow alga Chlamydomonas nivalis after exposure to UV light. J. Applied Phycology, 11:559-566.
  • Andarwulan, N., Fardiaz, D., Wattimena, G.A. and Shetty, K. (1999). Antioxidant activity associated with lipid and phenolic mobilization during seed germination of Pangium edule Reinw. J. Agric. Food. Chem., 47:3158-3163.
  • Andarwulan, N. and Shetty, K. (1999). Phenolic synthesis in differentiated tissue cultures of untransformed and Agrobacterium-transformed roots of anise (Pimpinella anisum L.). J .Agric. Food Chem., 47:1776-1780.