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Chris M. Olson, Jr.
-PhD-
EMail |
Chris is studying the local response to Borrelia burgdorferi in the infected heart. He has established the role of invariant NKT cells during infection with the spirochete and the phaogocytosis mechanisms by macrophages to the bacterium. He defended his thesis on April 17th, 2009. |
- M.N. Hedrick, C.M. Olson, D. Conze, T.C. Bates, M. Rincon, J. Anguita. 2006. Control of Borrelia burgdorferi-specific CD4+ T cell effector function by IL-12- and TCR-induced p38 MAP kinase activity. Infection and Immunity. 74:5713-5717.
- C.M. Olson, M.N. Hedrick, H. Izadi, T.C. Bates, E.R. Olivera, J. Anguita. 2007. p38 MAP kinase controls NF-kB transcriptional activation and TNFa production through RelA phosphorylation mediated by MSK1 in response to Borrelia burgdorferi antigens. Infection and Immunity. 75:270-277.
- C.M. Olson, T.C. Bates, H. Izadi, J.D. Radolf, S.A. Huber, J. Boyson, J. Anguita. 2009. Local production of Interferon gamma by invariant natural killer T cells modulates acute Lyme carditis. The Journal of Immunology. 182:3728-3734. doi:10.4049/jimmunol.0804111
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Hooman Izadi
-PhD Student-
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Hooman is interested in the role of c-Jun-mediated responses to Borrelia burgdorferi by macrophages. He has demonstrated that JNK1 regulates the expression of Toll-like Receptor 1 in phagocytic cells. In complex with TLR-2. TLR-1 are important pattern recognition receptors that interact with lipoproteins of the spirochete, which are major proinflammatory factors. He will defend his thesis during the Spring of 2010.
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- H. Izadi, A.T. Motameni, T.C. Bates, E.R. Olivera, V. Villar-Suarez, I. Joshi, R. Garg, B.A. Osborne, R.J. Davis, M. Rincón, J. Anguita. 2007. c-Jun N-Terminal kinase 1 is required for toll-like receptor 1 gene expression in macrophages. Infection and Immunity. 75:5027-5034.
- X. Yang, H. Izadi, A.S. Coleman, P. Wang, Y. Ma, E. Fikrig, J. Anguita, U. Pal. 2008. Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial sells through a protein moiety. Microbes and Infection. 10:1300-1308.
- C.M. Olson, T.C. Bates, H. Izadi, J.D. Radolf, S.A. Huber, J. Boyson, J. Anguita. 2009. Local production of Interferon gamma by invariant natural killer T cells modulates acute Lyme carditis. The Journal of Immunology. 182:3728-3734. doi:10.4049/jimmunol.0804111
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Kelly Hawley
-PhD Student-
EMail |
Kelly started her graduate work in January, 2009. Her project deals with the in vivo role of p38 MAP kinase during macrophage responses to Borrelia burgdorferi. She is analyzing new lines of transgenic mice that specifically express a dominant negative form of p38 MAPK in macrophages.
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Abhi is studying the role of the immune system in the activity of anti-bacterial polymers, and is part of Dr. Greg Tew's team. |
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