UMASS Amherst: Energy Metabolism Laboratory

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1. Insulin Resistance/Type 2 diabetes and 

2. Sex Differences in the Response to Exercise.

Publications related to insulin resistance and/or type 2 diabetes:

Sharoff CG, TA Hagobian, SR Chipkin, H Yu, MF Hirshman, LJ Goodyear, B Braun. Combined effects of metformin and exercise on insulin action in insulin resistant individuals.  Am. J. Physiol: Comp. Reg. Physiol.  in review

Hasson R, K Granados, DX Marquez, G Bennett, PS Freedson, B Braun. Psychosocial Responses to Acute Exercise in Sedentary Black and White Individuals. J. Phys. Act. Health, in review

 Hasson RE, Freedson PS, Braun B. Use of Continuous Glucose Monitoring in Normoglycemic, Insulin Resistant Women. Eur. J. Appl. Physiol. in press.

Malin SK, Stephens BR, Sharoff CG, Hagobian TA, Chipkin SR, Braun B. Exercise and post-exercise substrate oxidation are altered by metformin treatment.  Int. J. Sport Nutr. Metab. in press

 Holtz, K.A., Stephens, B.R., Sharoff, C.G., Chipkin, S.R., and Braun, B.  The effect of carbohydrate availability following exercise on whole body insulin action. Appl Physiol Nutr Metab. 33:946-56, 2008.

Braun B, Eze P, Stephens BR, Hagobian TA, Sharoff CG, Chipkin SR, Goldstein B. Impact of metformin on peak aerobic capacity.  Appl Physiol. Nutr. Metab.  33:61-67, 2008.

Stephens BR,  Sautter JM, Holtz KA, Sharoff CG, Chipkin SR, Braun B. Effect of timing of energy/carbohydrate replacement on post-exercise insulin action. Appl Physiol. Nutr. Metab. 32:1139-47, 2007.

Hasson RE, Freedson PS and B Braun.  Effect of Prior Exercise on Insulin Action in African-American Women. J Nat. Med. Assoc. 98(11):1832-39, 2006

Gerson LS and B Braun. Effect of high cardiorespiratory fitness and high body fat on insulin resistance. Med Sci Sports Exerc. 38:1709-15, 2006

Hagobian TA and B Braun Interactions between energy surplus and acute exercise on glucose and insulin responses in healthy people with induced, mild insulin resistance.  Metabolism: Clinical and Experimental: 55:402-08, 2006

Black SE, E Mitchell, PS Freedson, SR Chipkin, B Braun. Improved insulin action following short-term exercise training: role of energy and carbohydrate. J Appl Physiol. 99:2285-93, 2005

Chipkin SE, SE Black and B Braun. The Balance between Exercise and Diet: Impact on Insulin Sensitivity. Curr. Opin. Endocrinol. 12:152-56, 2005

Braun B, C Sharoff, SR Chipkin, F Beaudoin.  Effects of Insulin Resistance on Substrate Utilization During Exercise in Overweight Women. J Appl Physiol  97:991-7, 2004.

Older Publications:

Braun B, Friedlander AL, Pollack M, Butterfield GE, Marcus R, Hoffman AR. Five weeks of IGF-I treatment does not alter glucose kinetics or insulin sensitivity during a hyperglycemic clamp in older women Metabolism: Clinical and Experimental: 52:1182-90, 2003.

Braun B, Zimmermann MB , Kretchmer N.  Relationships between glucose metabolism and thermogenesis, with and without prior exercise, in women with NIDDM. Metabolism: Clinical and Experimental  45:747-52, 1996

Braun B, Zimmermann MB , Kretchmer N, Spargo RM, Smith RM, Gracey M.  Risk factors for diabetes and cardiovascular disease in young Australian Aborigines: A 5-year follow-up study. Diabetes Care 19:472-79, 1996

Braun B, Zimmermann MB, Kretchmer N.  Effects of exercise intensity on insulin sensitivity in women with NIDDM.  J Appl Physiol 78: 300-06, 1995 

Sex Differences in the Response to Exercise:

Publications:

Hagobian TA and B Braun.  Physical Activity and Hormonal Regulation of Appetite: Sex Differences and Implications for Weight Control.  Exerc. Sport Sci. Rev.  in press Volume 38.1, available January 2010.

Hagobian TA, Sharoff CG, Stephens BR, Wade GN, Chipkin SR, Silva EJ, Braun B. Effects of exercise on energy regulating hormones in men and women. Amer. J. Physiol: Comp. Reg. Physiol. 296: R233-42, 2009.

Hagobian TA, Sharoff CG and Braun B. Effects of acute exercise and energy surplus on hormones related to regulation of energy balance. Metabolism. 57:3293-98, 2008.

Braun B, Gerson L, Hagobian TA, Grow D, Chipkin SR. No Effect of Short-Term Testosterone Manipulation on Exercise Substrate Metabolism in Men. J Appl Physiol. 99:1930-37, 2005 

D'Eon TM, Sharoff CG, Chipkin SR, Grow D, Ruby BC, Braun B.  Regulation of exercise carbohydrate metabolism by estrogen and progesterone in women.  Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E1046-55.

D'Eon T, Braun B.  The roles of estrogen and progesterone in regulating carbohydrate and fat utilization at rest and during exercise.  J Womens Health Gend Based Med. 2002 Apr;11(3):225-37.

Braun B, Horton T. Endocrine regulation of exercise substrate utilization in women compared to men. Exerc Sport Sci Rev. 2001, 29(4):149-54.

Horton T. and B. Braun.  "Sex-based differences in substrate metabolism" in: Advances in Molecular and Cell Biology, 34: Principles of Sex-Based Differences in Physiology. VM Miller and M Hay, eds., Elsevier Publishing Co., Amsterdam , The Netherlands, page 209-228, 2004

Braun B, Butterfield G, Dominick S, Zamudio S, McCullough R, Rock P, Moore L.  "Women at Altitude: Changes in carbohydrate metabolism at 4300 meters elevation across the menstrual cycle".  J Appl Physiol 85: 1966-73, 1998.

30 Eastman Lane

Room 3, Energy Metabolism Lab

Phone: 413-545-0331

email: bbraun@excsci.umass.edu