UMass Amherst
 

  Biochem 523: General Biochemistry

Fall 2011
ISB 221
MWF
11:15-12:05


Instructors:

Robert A. Zimmermann (zimmermann@biochem.umass.edu) and
  Alejandro P. Heuck (apheuck@biochem.umass.edu)
 

Today is


aGal
Class Day Date Topics

Reading
PC = Pratt & Cornely

Links Covered
Notes
Lec 1

W

7 Sep

Course Description

 

Course info;Lec1

Q1, E1

 

Lec 2

F

9 Sep

Overview

PC 1-1 to 1-4

Lec2 pdf

Q1, E1

 

Lec 3

M

12 Sep

Aqueous Chemistry

PC 2-1 to 2-4

Lec3 pdf

Q1, E1

 

Lec 4

W

14 Sep

Nucleic Acid Structure

PC 3-1, 3-4

Lec4 pdf

Q1, E1

 

Lec 5

F

16 Sep

Protein Structure

PC 4-1 to 4-4

Lec5 pdf

Q1, E1

 

Lec 6

M

19 Sep

Quiz 1; Protein-Nucleic Acid-Interaction

TBA

Practice Quiz 1 & key;

Lec6 pdf & flash

E1

Add/Drop deadline

Lec 7

W

21 Sep

Protein Folding

PC PC 4-4, TBA

Lec7 pdf & flash

E1

 

Lec 8

F

23 Sep

Protein Purification/Analysis

PC 4-5

Lec8 pdf & flash

E1

 

Lec 9

M

26 Sep

Myoglobin/Hemoglobin PC 5-1

Lec9 pdf & flash

E1

 

Lec 10

W

28 Sep

Structural/Motor Proteins

PC 5-2 to 5-3

 

Q2, E2

 

Lec 11

F

30 Sep

Review and Problems

 

Lec10 pdf & flash

 

 

 

M

3 Oct

Exam 1: 7-9pm Morril 2 room 131

Make-ups held during class period*

E1 study guide

 

 

Lec 12

W

5 Oct

Enzymes: Introduction

PC 6-1 to 6-2

Lec12 pdf & flash

Q2, E2

 

Lec 13

F

7 Oct

Enzymes: Mechanism

PC 6-3 to 6-4

Lec13 pdf & flash

Q2, E2

 

 

M

10 Oct

Holiday

 

 

 

Columbus Day

Lec 14

T

11 Oct

Enzymes: Kinetics

PC 7-1 to 7-3

Q2 study guide;

Lec 14 pdf

Q2, E2

 

Lec 15

W

12Oct

Quiz 2, Ribozymes; Riboswitches

TBA

Lec 15 pdf

E2

 

Lec 16

F

14 Oct

Reading Papers

TBA

Lec 16 pdf

E2

 

Lec 17

M

17 Oct

Xeroderma Pigmentosum

TBA

Lec 17 pdf E2

 

Lec 18

W

19 Oct

Bioinformatics

PC 3-3 Boxes 3-2, 4-3

Lec 18 pdf

E2

 

Lec 19

F

21 Oct

Review and Problems

 

Lec 19 pdf

E2

 

 

M

24 Oct

Exam 2: 7-9pm Morril 2 room 131

Make-ups held during class period*

Exam 2 study guide

 

 

Prof Zimmermann finishes

Lec 20

W

26 Oct

Intro to Biological membranes

PC Chp 8.1 pp 215-222

Advanced reading lipids pdf

The fluid mosaic model original paper pdf

 

Lec 20 pdf & flash

E3 Q3

Prof Heuck starts

Lec 21

F

28 Oct

Membrane structure and membrane proteins. Movie file.

 

PC 8.2-end pp 222-234

Advanced reading PS pdf

 

Lec 21 pdf & flash

E3 Q3

 

Lec 22

M

31 Oct

University is closed

Science Entreprenures Forum info pdf

 

 

 

Lec 23

W

2 Nov

Membrane proteins and intro to transport

PC Ch 9.1-end pp 235-318

Lec 22 pdf & flash

E3 Q3

 

Lec 24

F

4 Nov

Membrane transport

 

Study guide Quiz 3 pdf

Lec 23 pdf & flash

Practice Q3 and key

E3 Q3

 

Lec 25

M

7 Nov

Quiz 3, Metabolic pathways

PC Ch 12.1-12.3 pp 296-316

Lec 24 pdf & flash

E3

Quiz 3 key

W

9 Nov

Metabolic reactions and free energy changes

Lec 25 pdf & flash

Study guide pdf

 

F

11 Nov

Holiday Veteran's Day

Review concepts on Carbohydrates

Chapter 11 study guide pdf.

E3

Veteran's Day

Lec 26

M

14 Nov

Review

Practice Exam3 ...../......... Key

Review flash

E3

 

 

W

16 Nov

Exam 3: 7-9pm Morril 2 room 131

Make-ups held during class period*

Ch 8, 9, and 12 as covered in class.

 

 

Lec 27

F

18 Nov

Glucolysis

PC Ch 13.1 - 13.2 pp 337-344

Lec 27 pdf & flash

Study guide pdf. The fate of pyruvate Key

E4 Q4

 

Lec 28

M

21 Nov

Glucolysis

 

Advanced reading on metabolism pdf.

Lec 28(on 27) & flash

 

E4 Q4

 

Lec 29

W

23 Nov

The fate of pyruvate. Gluconeogenesis.

PC Ch 13

Lecture slides after class 2010 pdf

Lec 29 pdf & flash

Study guide pdf. Cytric acid cycle Key

E4 Q4

Exam 3 grades posted on SPARK Average 83 SD 13

 

F

25 Nov

Holiday

Practice Q4 and key

 

 

Happy Thanksgiving!

Lec 30

M

28 Nov

Quiz 4, The cytric acid cycle (CAC)

PC Ch 14 pp 359-383

Advanced reading on Citric Acid Cycle pdf

Lec 30 pdf & flash

 

E4 Q4

 

Lec 31

W

30 Nov

Finish CAC. Oxidative phosphorylation

.

PC Ch 15.1-2 pp384-398

Exam 3 key

Lec 31 pdf & flash

Lec 31 slides after class pdf

Study guide pdf. Oxidative phosphoriration Key

E4

Quiz 4 key

Average 22.1

Stdev 5.7

Lec 32

F

2 Dec

Oxidative phosphorylation

 

 

Lec 32 pdf & flash Study guide pdf. Oxidative phosphorilation2 Key

E4

Want a paid intership? pdf

Lec 33

M

5 Dec

Oxidative phosphorylation

PC Ch 15.3-4 pp398-408

 

Lec 33 pdf & flash

E4

 

Lec 34

W

7 Dec

ATP synthase

Lac 34 slides after class pdf

Capaldi & Aggeler 2002

Movies link

Lec 34 pdf & flash Study guide pdf. ATPsynthase Key

E4

 

Lec 35

F

9 Dec

Review 2 Practice Exam4 pdf

Key

Exam 4 prep notes pdf

Lec 35 pdf & flash

E4

 

Exam 4

F

16 Dec

Exam 4 Morrill Sci Ctr (I) rm N329

1:30 PM to 3:30 PM

Exam 4 key NEW

Office hours AH Tuesday 4-6 PM

TA Wednesday 11AM 1PM Lederle 814

Study hard!

Exam 4 average was 79 with a standard deviation of 12

*Make-up exams must be arranged in advance.